Endocrine Abstracts

Background: Glycaemia point-of-care testing (POCT) is performed with fingerstick capillary whole-blood glucose measurement. These values normally correlate well with plasma glucose values. Hypoglycemia can be observed with POCT but should always be confirmed on plasma. True hypoglycemia must meet Whipple’s triad: signs/symptoms of hypoglycemia; low plasma glucose; improvement after glucose administration. Artifactual hypoglycemia is defined as a discrepancy between POCT a...

Context: Maturity-Onset Diabetes of the Young (MODY) refers to a group of monogenic β cell disorders1. MODY12 comprises various mutations in the ATP-binding cassette transporter subfamily C member 8 (ABCC8) gene of the ATP-sensitive potassium (K-) channel and is a condition that is not frequently encountered, comprising 1% of all MODY types1. Gain-of-function ABCC8 mutations can result in neonatal diabetes mellitus and/or MODY12, whereas loss-of-fun...

Background and aims: Insulin resistance is increasingly prevalent in patients with type 1 diabetes (T1D). Insulin resistance is associated with both cardiovascular complications and non-alcoholic fatty liver disease (NAFLD), but its assessment is challenging in T1D due to the technical difficulties of the euglycaemic clamp technique. The estimated glucose disposal rate (eGDR) is a validated alternative to quantify insulin resistance in T1D, but its role in clinical practice is...

Background and aims: The prevalence of sexual dysfunctions in people with diabetes is still debated and understudied in women. This study examines the prevalence of sexual dysfunction in men and women with type 1 or type 2 diabetes (T1D or T2D) and the associations with clinical and psychological variables.Methods: Adults with diabetes (n756) completed an online survey including questions on sexual functioning (adapted Short Sexual Functional Sc...

Introduction: Nonalcoholic fatty liver disease (NAFLD) affects ±55% of subjects with type 2 diabetes and contributes to cardiovascular mortality. NAFLD data in type 1 diabetes (T1DM) are scarce. Biopsy is the diagnostic reference but is not suited for routine screening. Ultrasound (US) is validated to diagnose steatosis as first-line imaging but is restricted to trained operators. The Fatty Liver Index (FLI) is a score to predict fatty liver based on triglycerides, Body M...

Objective: Nation-wide reimbursement of intermittently scanned continuous glucose monitoring (isCGM) for people with type 1 diabetes was introduced in Belgium in 2016. We investigated whether diabetes knowledge and health literacy would impact glycemic control after one year of isCGM use.Research design and methods: In this substudy of the FUTURE trial, a prospective observational real-world cohort study in individuals with type 1 diabetes ≥16 year...

Background and Aims: To evaluate whether switching from traditional mealtime insulin analogs to fast-acting insulin aspart (Fiasp) in routine clinical practice is efficacious and safe in adult people with type 1 diabetes (PWD1) using intermittent or real-time continuous glucose monitoring (iCGM or rtCGM).Methods: Data from 438 adult PWD1 (60% men, age 44.6±16.1 years, duration of diabetes 21.5±14.0 years, iCGM/rtCGM: 391/47, injections/pump: 409/29...

Aims: To determine predictors of neonatal adiposity and differences in associations by fetal sex in women with gestational diabetes mellitus (GDM), normal-weight and overweight (BMI ≥ 25 kg/m²) normal glucose tolerant women (NGT).Methods: Skinfold thickness was measured in 576 newborns, and cord blood leptin, c-peptide and lipids in 327 newborns in a multi-centric prospective cohort study.Results: Compared to ...

Aims: To determine the fasting plasma glucose (FPG) level at which an oral glucose tolerance test (OGTT) could be avoided to screen for gestational diabetes (GDM) and to evaluate the characteristics of women across this FPG threshold.Methods: A multi-centric prospective cohort study (BEDIP-N) with 1843 women receiving screening for GDM with a 75g OGTT.Results: A FPG < 78 mg/dl was the FPG cut-off with the best trade-off to limi...

Aims: To determine the impact of antenatal depression on pregnancy outcomes in women with gestational diabetes mellitus (GDM) and women with normal glucose tolerance (NGT).Methods: 1843 women from a Belgian multi-centric prospective cohort study (BEDIP-N Study) received universal screening for GDM with a 75 g OGTT and the IADPSG criteria. The Center for Epidemiologic Studies – Depression (CES-D) questionnaire was completed at the time of the OGTT (b...